Gene: [00.0/EREG] epiregulin (EGF-related growth regulating peptide);

FUN

[1] Epiregulin functions as a tumor growth-inhibitory factor inducing morphologic changes in HeLa cells (Toyoda-1995).
[2] In mice, epiregulin exhibited bifunctional regulatory properties: it inhibited the growth of several epithelial tumor cells and stimulated the growth of fibroblasts and various other types of cells (Toyoda-1995)."

EXP

The level of expression of epiregulin was extremely low almost in all tissues but clearly detectable in macrophages and placenta and was high in carcinoma cells (Toyoda-1997)."

REF

FUN "Komurasaki T &: Oncogene, 15, N23, 2841-2848, 1997
COD,SEQ,EVO "Toyoda H &: Biochem J, 326, (Part 1), 69-75, 1997
FUN,EXP "Toyoda H &: JBC, 270, N13, 7495-7500, 1995

KEY

onc, trp

CLA

coding, basic

LOC

RS

MIM

MIM: 602061