Gene: [00.0/GLIPR] glioma pathogenesis-related protein; related to testis-specific, vespid, and pathogenesis proteins 1; glioma, type ?; [RTVP1 ]

EVO

GLIPR/RTVP1 protein has significant sequence identity to the mammalian testis-specific proteins (e.g., GEM:06^/TSP2), a rat sperm coating glycoprotein (Scg), the vespid venom allergen antigen-5 (Ag5), and a family of plant pathogenesis-related proteins (PR)."

EXP

Under stringent conditions, Northern blot analysis detected 3 predominant mRNAs of 4.2, 3.2, and 1.1 kb. In fetal tissues, RTVP1 RNA was expressed only in the kidney. In adult tissues, its expression was ubiquitous, with high levels in lung and kidney and low levels in heart and liver. Only the 4.2-kb transcript was detected in the brain. Multiple RTVP1 mRNAs were highly expressed in cell lines derived from nervous system tumors arising from glia, although expression was low or absent in non-glial-derived nervous system tumor cell lines (Rich-1996)."

REF

COD,SEQ,TIS "Murphy EV &: Gene, 159, 131-135, 1995
COD,SEQ,EVO "Rich T &: Gene, 180, 125-130, 1996
FUN "Szyperski T &: PNAS, 95, N5, 2262-2266, 1998

SWI

SWISSPROT: P48060

KEY

neu, onc

CLA

coding, basic

LOC

RS

MIM

MIM: 602692

SYN

RTVP1