Gene: [01q2/POU2F1] POU domain, class 2, transcription factor 1; octamer-binding transcription factor 1 (B-cell specific); [OTF1 OCT1 ]

FUN

Products of the OTF genes are thought to bind octanucleotide ATTTGCAT, which is contained in promoters of immunoglobulin genes and plays a critical role in the tissue-specific restriction of their expression, predominantly by lymphoid cells."

REF

IDN,FUN,EXP "Fletcher C &: Cell, 51, N5, 773-781, 1987
PRO,LOC "Hsieh CL &: Genomics, 6, 666-672, 1990
PRO,LOC "Hsieh CL &: CCG, 51, (HGM10), 1016, 1989
MAF,MOU "Oakey RJ &: Hum Mol Genet, 1, 613-620, 1992
LOC,MAF "Sturm RA &: CCG, 68, 231-232, 1995
EXP "Sturm RA &: Genomics, 16, 333-341, 1993
LOC,SEQ "Sturm RA &: Genes Dev, 2, 1582-1599, 1988

KEY

trc, imm, img

CLA

coding, basic

LOC

01 q22-23

MIM

MIM: 164175

SYN

OTF1 OCT1