Gene: [02^/TSE2] tissue specific extinguisher 2;

COM

Tissue-specific gene expression is generally extinguished in somatic cell hybrids formed by fusing different cell types. The extinction phenomenon has been long studied as a paradigm for developmental and tissue-specific gene control. The extinction in hepatoma/fibroblast hybrids involves a comprehensive loss of liver-specific gene activity, including expression of liver-enriched transcription factors. Extinction of liver gene expression in hepatoma hybrids occurs at the level of transcription, resulting in a 1,000-fold reduction in steady-state levels of liver-specific mRNAs. Furthermore, extinction is reversible: as the hybrids segregate chromosomes of their nonhepatic parents, liver genes are reexpressed. Thus, extinction is an active process that requires the continuous presence of fibroblast loci that function in trans (Cerosaletti-1996). Cerosaletti and Fournier
(1996) favored the view that multiple extinguisher loci reside on human chromosome 2."

FAG

The product of the TSE1 locus was identified as the the regulatory subunit RI-alpha of protein kinase A (GEM:17q2/PRKAR1A)."

REF

LOC,REV "Cerosaletti KM, Fournier REK: Genomics, 31, 348-358, 1996

KEY

trc

CLA

coding, basic

LOC

02

MIM

MIM: 601136

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