Gene: [02p16/XPO1] exportin 1 (required for chromosome region maintenance; CRM1, yeast, homolog); [CRM1 ]

COM

[1] The XPO1 gene was mapped to Chr 2p16 by FISH (Fornerod-1997).
[2] CRM1, or XPO1, is the homolog of yeast crm1 (named for 'required for chromosome region maintenance'), a nuclear protein essential for proliferation and chromosome region maintenance."

FUN

CRM1 protein binds CAN and NUP88 (GEM:17p13/NUP88), and its association with the nuclear pore is dynamic. CRM1 is an export receptor for leucine-rich nuclear export signals (Fornerod-1997b)."

REF

COD "Fornerod M &: Cell, 90, 1051-1060, 1997a
LOC,FAG "Fornerod M &: Genomics, 42, 538-540, 1997b
COD,SEQ "Kudo N &: JBC, 272, 29742-29751, 1997
COD,FUN "Stade K &: Cell, 90, 1041-1050, 1997
REV "Ullman KS &: Cell, 90, 967-970, 1997

KEY

chr

CLA

coding, basic

LOC

02 p16

MIM

MIM: 602559

SYN

CRM1