Gene: [02q333/IDH1] isocitrate dehydrogenase 1 (NADP+), soluble;

COM

HGM indicates a less definite location for IDH1: 2q32-qt.

FAG

A mitochondrial isoform is encoded by the nuclear gene mapped in Chr 15q2 (GEM:15q2/IDH2). See also GEM:15q25/IDH3A; GEM:00.0/IDH3B; GEM:0Xq28/IDH3G."

FUN

The catalyzed reaction: isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH."

REF

FUN,FOG "Chen &: AJHG, 24, 325-329, 1972
LOC "Creagan &: AJHG, 26, 604-613, 1974
LOC "Hamerton JL &: AJHG, 27, 595-608, 1975
LOC "Narahara K &: Hum Genet, 71, 37-40, 1985
LOC "Weil &: Hum Genet, 36, 205-211, 1977

KEY

cytr

CLA

coding, basic

LOC

02 q33.3

MIM

MIM: 147700

EZN

ENZYME: 1.1.1.42