Gene: [03p21/GNAI2] guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; adenylate cyclase inhibitor GI, alpha-I2 (GIP2 oncogene); adrenal cortical tumor (granulosa cell tumor; thecoma); pituitary adenoma, adrenocorticotrophin hormone-secreting; [GNAI2B GIP2 ]

GEN

The gene length is about 16 kb. Exons: 8; introns: 7. The gene structure is identical to that of the gene coding for alpha-I3 peptide (GEM:01p13/GNAI3). Human mRNA is 2.6 kb. The 5'-flanking region is located 800 bp apart from ATG initiation codon. The promoter region contains two typical CCAAT blocks positioned 262 and 411 bp before the start, seven CCGCCC blocks, positioned 24, 62, 171, 220, 273, 382, and 455 bp before the start, as well as GC and GGGCGG (or its complement) blocks. Typical TATA-like sequences have not been found."

EVO

The amino acid sequence of human alpha-I2A protein differes from that of bovine alpha-I protein by 12%. A considerable similarity occurs between the human coding region and rat GI2S (92-99%). The homology of their flanking regions is 89%."

EAG

The identical murine gene is located in chr 9.

FAG

For more details on GN gene family, see FAM:GNBP/00.0.

REF

LOC,MOL "Blatt C &: PNAS, 85, N20, 7642-7646, 1988
FAG,SEQ "Bray P &: PNAS, 84, N15, 5115-5119, 1987
MUT,EXP,FUN "Hermouet S &: PNAS, 88, 10455-10459, 1991
SEQ,GEN,HUM,RAT,EVO "Itoh H &: JBC, 263, N14, 6656-6664, 1988
HUM,FUN,EXP,FAG "Kim SY &: PNAS, 85, N12, 4153-4157, 1988
MUT,ASS,PAT,ABR,FAG "Lyons J &: Science, 249, 655-659, 1990
PRO,LOC,FAG "Magovcevic I &: Genomics, 12, 125-129, 1992
LOC,MOL "Sparkes RS &: CCG, 46, (HGM9), 696, 1987
MUT,PAT "Williamson EA &: Eur J Clin Invest, 25, 128-131, 1995

KEY

neu, nucm, onc

CLA

coding, basic

LOC

03 p21.3-.2

MIM

MIM: 139360

SYN

GNAI2B GIP2

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