Gene: [05q23/DTR] diphtheria toxin receptor; heparin-binding epidermal growth factor-like growth factor; diphtheria toxin sensitivity; [DTS HEGFL ]

HIS

The linkage between the DTS locus and chr 2 markers was erroneously determined by Roberts,Ruddle-1980. Later the gene responsible for diphtheria toxin sensitivity was assigned to chr 5 in independent studies of various authors (Creagan-1975a and others). In 1987, its regional location in 5q23 was determined by Hayes-1987 and confirmed by Fen-1993."

FUN

Higashiyama-1991,1992 showed that DTR is integral membrane protein and identical to heparin-binding epidermal growth factor-like growth factor."

REF

LOC,CYG "Athwal RS &: J Hered, 76, 329-334, 1985
FUN,EVO,MUT "Chang, Neville: JBC, 253, 6866-6871, 1978
LOC,CYG "Creagan RP &: CCG, 14, 279-281, 1975a
LOC,CYG "Creagan RP &: PNAS, 72, 2237-2241, 1975b
CLO,SEQ,GEN,LOC "Fen Z &: Biochemistry, 32, 7932-7938, 1993
LOC,CYG "George DL, Francke: Somat Cell Genet, 3, 629-638, 1977
FUN,EVO,MUT "Gupta, Siminovitch: PNAS, 75, 3337-3340, 1978
LOC,CYG "Hayes H &: Chromosoma, 96, 26-32, 1987
CLO,SEQ,STR,EXP,FUN "Higashiyama S &: JBC, 267, 6205-6212, 1992
CLO,SEQ,STR,EXP,FUN "Higashiyama S &: Science, 251, 936-939, 1991
FUN,EVO,MUT "Pappenheimer AM: Annu Rev Biochem, 46, 69-94, 1977
COM,LIN,HIS "Roberts, Ruddle: Exp Cell Res, 127, 47-54, 1980
LOC,CYG "Ruddle FH &: CCG, 16, 31-53, 1976

SWI

SWISSPROT: Q99075

KEY

mem, recp

CLA

coding, basic

LOC

05 q23

MIM

MIM: 126150

SYN

DTS HEGFL

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