Gene: [06q15/RNRS] nucleolus organizer regions NOR-S (NOR suppl in 6q); [NORS ]

COM

This locus is not a canonical one, and must be classified as a genome variant, for it is currently determined only in one family by standard cytogenetical methods and is not confirmed by the molecular ones. In the nuclear family of 5 persons, the proband (a premature infant with the developmental anomalies), one of his healthy brothers, and the father had the insertion of NOR material into the segment 6q14-15. This follows from the presence of the atypical secondary constriction which is similar to the NOR chromosome satellite strand, in 100% methaphases, from the positive result of silvering and from the high frequency of associations of the segment with D and G chromosomes."

REF

LOC,CYG "Prieto F &: Hum Genet, 81, 289-290, 1989

KEY

trl

CLA

unknown, basic

LOC

06 q15

MIM

?

SYN

NORS