Gene: [07q11/ZWS1] Zellweger syndrome 1 (cerebrohepatorenal); [ZS CHR ]

COM

Using the data of Naritomi-1989, one could map ZWS to a narrower subsegment Chr 7q11.23."

HET

[1] MIM, under the number MIM:214110, registered another type of this syndrome, which is considered as an independent genetic variant, although the corresponding gene is not mapped yet (Brul-1988).
[2] Zellweger syndrome phenotype is caused by mutations in any of several different genes involved in peroxisome biogenesis, e.g. peroxin-5 (GEM:12p13/PXR1), peroxin-2 (GEM:08q211/PXMP3), peroxin-6 (GEM:06p211/PEX6), and peroxin-12 (GEM:00.0/PEX12)."

REF

COM,PAT "Brul S &: J Clin Invest, 81, N6, 1710-1715, 1988
PAT,PHE "Erdem G &: Am J Med Genet, 58, N2, 152-154, 1995
REV,HET "Moser AB &: J Pediatr, 127, N1, 13-22, 1995
LOC,CYG "Naritomi K &: Hum Genet, 84, 79-80, 1989
LOC,CYG "Naritomi K &: Hum Genet, 80, 201-202, 1988

KEY

neu, ren, devd

CLA

unknown, basic

LOC

07 q11

MIM

MIM: 214100

SYN

ZS CHR

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