Gene: [07q35/PRSS1] protease, serine, 1 (trypsin 1); trypsin 1; trypsinogen deficiency; pancreatitis, hereditary (calcific; MIM:167800);

COM

Rowen-1996 narrowed the assignment somewhat to Chr 7q35.

FUN

Systematic name is not yet assigned. Trypsin catalyzes hydrolysis of peptide bonds. The preferential cleavage: Arg-|-Xaa, or Lys-|-Xaa."

REL

GEM:07q35/PRSS2; GEM:00.0/PRSS3; GEM:00.0/PRSS4; GEM:03q2/PRSS5; GEM:00.0/PRSS6; GEM:21q21/PRSS7; GEM:16p112/PRSS8; GEM:19q133/PRSS9; GEM:10q2/PRSS11, GEM:19q133/PRSSL1. See also GEM:02p12/PAP."

REF

PRO,SEQ,FAG,EXP "Craik CS &: JBC, 259, 14255-14264, 1984
PRO,SEQ,FAG,EXP "Emi M &: Gene, 41, 305-310, 1986
PRO,LOC,CYG,FAG,EVO "Honey NK &: CCG, 37, (HGM7), 492, 1984a
PRO,LOC,CYG,FAG,EVO "Honey NK &: Somat Cell Mol Genet, 10, 369-376, 1984b
PRO,SEQ,FAG,EXP "Kimland M &: Clin Chim Acta, 184, 31-46, 1989
PAT,LOC,LIN "Le Bodic L &: Hum Mol Genet, 5, 549-554, 1996
PRO,LOC,CYG,FAG,EVO "Naylor SL &: CCG, 46, 669, 1987
PAT,LOC,LIN "Pandya A &: Genomics, 38, N2, 227-230, 1996
GEN,SEQ,LOC,FAG "Rowen L &: Science, 272, 1755-1762, 1996
PAT "Townes PL &: J Pediatr, 71, 220-224, 1967
PAT "Townes PL: J Pediatr, 66, 275-285, 1965
PAT,LOC,LIN "Whitcomb DC &: Gastroenterology, 110, 1975-1980, 1996a
PAT,MUT "Whitcomb DC &: Nature Genet, 14, 141-145, 1996b

SWI

SWISSPROT: P07477

KEY

git, pep

CLA

coding, basic

LOC

07 q35

MIM

MIM: 276000

EZN

ENZYME: 3.4.21.4