Gene: [08q242/PSCA] prostate stem cell antigen; prostate cancer?;

COM

The PSCA gene was mapped to chromosome 8q24.2 by FISH (Reiter-1998).

FUN

PSCA may play a role in prostate cancer progression and may serve as a target for prostate cancer diagnosis and treatment (Reiter-1998)."

COD

"PSCA encodes a 223-amino acid protein with an amino-terminal signal
sequence, a carboxy-terminal GPI-anchoring sequence, and multiple
N-glycosylation sites. PSCA is homologous to a group of cell surface
proteins that mark the earliest phases of hematopoietic development.
PSCA mRNA expression is prostate-specific in normal male tissues (Reiter-1998)."

ASS

There is moderate to strong PSCA expression in 111 of 126 (88%) prostate cancer specimens examined by in situ analysis, including high-grade prostatic intraepithelial neoplasia and androgen-dependent and androgen-independent tumors."

REF

COD,SEQ,EXP,LOC "Reiter RE &: PNAS, 95, 1735-1740, 1998

KEY

onc, sex

CLA

coding, basic

LOC

08 q24.2

MIM

MIM: 602470