Gene: [09q22/CTSL] cathepsin L (major excreted protein, MEP);

FUN

[1] Takes part in lysosomal proteolysis. Belongs to thiol proteases.
[2] Systematic name: not known. Catalyzes hydrolysis of proteins. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg- NHMeC, and no peptidyl-dipeptidase activity."

FAG

See GEM:08p22/CTSB.

REF

LOC,CYG,MOL,FAG "Fan &: CCG, 51, (HGM10), 996, 1989
CLO,SEQ,EXP,EVO "Gal S, Gottesman: Biochem J, 253, 303-306, 1988
CLO,EXP "Joseph LJ&: J Clin Invest, 81, 1621-1629, 1988

SWI

SWISSPROT: P07711

KEY

pep, lys

CLA

coding, basic

LOC

09 q22.1-.2

MIM

MIM: 116880

EZN

ENZYME: 3.4.22.15

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