Gene: [10q24/HOX11] homeo box 11, homologous to Drosophila Notch; protooncogene TCL3; T cell lymphoma 3 associated breakpoint;

MUT

This type of lymphoma is frequently associated with the translocation 10q24/14q11, and a cluster of minigenes of alpha-peptide of the T cell receptor Ti component is located in 14q11. Therefore, these genes are supposed to be involved in the pathogenesis of this lymphoma; see also FAM:TCR1AD/14q112."

REL

GEM:00.0/HHEX.

REF

CLO,LOC,CYG "Dube ID &: CCG, 51, (HGM10), 993, 1989
LOC,CYG "Dube ID &: Blood, 67, 1181-1184, 1986
LOC,CYG "Kagan J &: PNAS, 84, N13, 4543-4546, 1987

KEY

imm, onc, hem

CLA

coding, basic

LOC

10 q24

MIM

MIM: 186770