Gene: [10q2/NRAP] nebulin-related anchoring protein;

COM

The NRAP gene was mapped to chromosome 10q24-q26 by use of PCR of a radiation hybrid panel (Luo-1997a)."

FUN

NRAP is localized at the myotendinous junction in skeletal muscle and the intercalated disc in cardiac muscle. It is suggested that NRAP performs an anchoring function, linking the terminal actin filaments of myofibrils to protein complexes located beneath the sarcolemma (Luo-1997b)."

PRT

"Sequence analysis predicted that NRAP is a 1,175-amino acid protein with
a pI of 9.26. The C-terminal half of NRAP includes an actin-binding
domain with homology to the nebulin super repeats. The N-terminal region
contains a LIM domain, thought to mediate protein-protein
interactions (Luo-1997b)."

FAG

Nebulin is a family of giant myofibrillar proteins found within the sarcomeres of skeletal muscle. The main nebulin gene has been mapped to Chr 2q24 (GEM:02q24/NEB)."

REF

LOC,EAG "Luo G &: Genomics, 45, 229-232, 1997a
MOU,COD,EXP,FUN "Luo G &: Cell Motil Cytoskeleton, 38, 75-90, 1997b

KEY

myo

CLA

coding, basic

LOC

10 q24-26

MIM

MIM: 602873