Gene: [10q2/SFTPA1] surfactant, pulmonary-associated protein A1 (SP-A1; 35kD); [SFTP1 PSPA ]

MOP

Surfactant-associated protein A1 (in contrast to highly hydrophobic peptides 2 and 3) is a water-soluble protein. It decreases the surface tensionin in lung alveoles through stimulation of the surfactant lipid uptake by type II alveolocytes and suppression of surface-active substance secretion by these cells."

PSG

GEM:10^/SFTPAP1.

REL

GEM:10q2/SFTPA2; GEM:02p1/SFTPB; GEM:08p21/SFTPC; GEM:10q2/SFTPD.

REF

EVO,SEQ "Benson &: PNAS, 82, N19, 6379-6383, 1985
LOC "Bruns G &: Hum Genet, 76, 58-62, 1987
FUN "Dobbs &: PNAS, 84, N4, 1010-1014, 1987
PRO,LOC,POL "Fisher JH &: AJHG, 40, 503-511, 1987
CLO,SEQ "Floros &: JBC, 261, 9029-9033, 1987
FAG "Glasser SW &: JBC, 263, N21, 10326-10331, 1988
CLO,SEQ "Glasser SW &: PNAS, 84, 4007-4011, 1987
LOC "Karinch AM &: Am J Respir Cell Mol Biol, 12, 77-88, 1995
SEQ "Katyal SL &: Am J Respir Cell Mol Biol, 6, 446-452, 1992
EVO,SEQ "Kolble K &: Genomics, 17, 294-298, 1993
FUN "Odom &: Endocrinology, 123, N4, 1712-1720, 1988
CLO,SEQ "White RT &: Nature, 317, 361-363, 1985
FUN "Wright &: JBC, 262, 2888-2894, 1987

KEY

pulm, exce

CLA

coding, basic

LOC

10 q22-23

MIM

MIM: 178630

SYN

SFTP1 PSPA

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