Gene: [11q13/CFL1] cofilin 1 (non-muscle); [CFL ]

COM

The CFL1 gene was mapped to chromosome 11q13 by fluorescence in situ hybridization (Gillett-1996)."

FUN

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus."

FAG

[1] A gene coding for another cofilin has been mapped to chr 14: GEM:14^/CFL2.
[2] About actin genes see in: FAM:ACT/00.0."

LIK

GEM:00.0/CFLL1; GEM:00.0/CFLL2; GEM:00.0/CFLL3; GEM:00.0/CFLL4.

REF

MAP "Courseaux A &: Genomics, 37, N3, 354-365, 1996
CLO,SEQ,STR,LOC "Gillett GT &: Ann Hum Genet, 60, 201-211, 1996
CLO,SEQ "Ogawa K &: NAR, 18, 7169, 1990

KEY

cysk

CLA

coding, basic

LOC

11 q13

MIM

MIM: 601442

SYN

CFL