Gene: [16q241/COX4] cytochrome c oxidase subunit IV;

PSG

GEM:14q/COX4P1.

EVO

The expressed COX4 gene in human, bovine, rat, and mouse and the COX4 pseudogene in human, chimpanzee, orangutan, squirrel monkey, and bovine were analyzed (Lomax-1992); from a comparison of the sequences, the sequence of the ancestral mammalian COX4 gene was constructed. Lomax et al. deduced that the human gene had evolved rapidly since the origin of the primate pseudogene approximately 41 million years ago and proposed that this resulted from coevolution of nuclear and mitochondrial genes for cytochrome c oxidase."

REF

LIN,MAP "Callen &: CCG, 58, (HGM11), 1998, 1991
PRO,LOC,MOL,FAG "Darras &: CCG, 46, (HGM9), 603, 1987
SEQ,EVO,EAG "Lomax MI &: PNAS, 89, 5266-5270, 1992
LOC,EAG "Lomax MI &: Gene, 86, 209-216, 1990

SWI

SWISSPROT: P13073

KEY

mito, mtbd

CLA

coding, basic

LOC

16 q24.1

MIM

MIM: 123864

EZN

ENZYME: 1.9.3.1