Gene: [17q21/HCRT] hypocretin (orexin) neuropeptide precursor; [PPOX ]

EXP

Two neuropeptides orexin A (hypocretin 1) and orexin B (hypocretin 2) are derived from the same precursor (preproorexin) by proteolytic processing. The orexin receptor 1 (GEM:01p33/HCRTR1) binds orexin A only, whereas orexin receptor 2 (GEM:06^/HCRTR2) binds both orexin A and orexin B."

REF

CLO,MOU "de Lecea L &: PNAS, 95, N1, 322-327, 1998
CLO,SEQ,EXP,LOC,EVO "Sakurai T &: Cell, 92, N4, 573-585, 1998

KEY

neu

CLA

coding, basic

LOC

17 q21

MIM

MIM: 602358

SYN

PPOX