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Форум
Биологические базы данных
Алфавитный указатель
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FUN | Two
hypothalamic releasing factors, growth hormone-releasing factor (GHRF) and
somatostatin (GEM:03q28/SST), participate in
regulating the complex process of growth hormone (GH) synthesis and
secretion in the anterior pituitary. While GHRF or somatocrinin
(Gubler-1983) functions as a specific stimulator of GH secretion,
somatostatin may act as an inhibitory counterpart (Guillemin-1982)."
| PAT | Mutations in GHRF were assumed to result in diseases with
growth hormone deficiency such as the familial isolated growth hormone
deficiency (IGHD) and pituitary dwarfism (Mitrakou-1985; Thorner-1988)."
| GEN | The gene length is about 10 kb. Exons: 5; introns: 4. The five
exons encode the functionally discrete domains of the precursor molecule,
with exon 3 encoding most of the mature GHRF peptide. An Alu-repeat was
identified upstream from exon 2 (Mayo-1985)." | MOP | GHRF is a 44-amino
acid peptide amidated at its COOH terminus. It is synthesized as a 107- and
108-amino acid precursor protein, preprosomatocrinin, with a MM of
approximately 13 kD (Gubler-1983; Mayo-1983)." | REF | FUN,ASS,SEQ,CLO
"Gubler U &: PNAS, 80, 4311-4314, 1983
FUN,PAT "Guillemin R &: Science,
218, 585-587, 1982
CLO,SEQ,ASS,GEN,EXP,LOC,CYG "Mayo KE &: PNAS, 82,
N1, 63-67, 1985
PAT "Mitrakou &: Lancet, 1, 399-400, 1985
LOC,FUN
"Rao VV &: CCG, 57, 39-40, 1991
CLO,SEQ,EXP,LOC,CYG "Riddell DC &:
Somat Cell Mol Genet, 11, 189-195, 1985
FUN,PAT "Rivier &: Nature, 300,
276-278, 1982
LOC,CYG,MOL "Shohat &: CCG, 51, (HGM10), 1078, 1989
PAT,TER "Thorner &: Pediatr Res, 24, 145-151, 1988
| SWI | SWISSPROT: P01286 | KEY | neu, horm
| CLA | coding, basic | LOC | 20 q11.2
| MIM | MIM:
139190 | SYN | GHRH |
Ссылки:
1. Ген соматолиберина
2. Фактор, высвобождающий гормон роста (GHRF)
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