Gene: [21q2212/CBR1] carbonyl reductase 1 (NADPH) (EC:1.1.1.184); prostaglandin-E2 9-reductase (EC:1.1.1.189); hydroxyprostaglandin dehydrogenase 15- (NADP+) (EC:1.1.1.197);

COM

McInnis-1993 assigned carbonyl reductase to Chr 21q22.3. Lemieux-1993 refined the location to Chr 21q22.12 by fluorescence in situ hybridization."

FUN

EC:1.1.1.184. Systematic name: secondary-alcohol:NADP(+) oxidoreductase. The catalyzed reaction: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol."

REL

GEM:00.0/CBR3.

REF

POL,LOC "Avramopoulos D &: Genomics, 15, 98-102, 1993
POL,LOC,LIN "Avramopoulos D &: Genomics, 13, N2, 447-448, 1992
MAP "Chumakov I &: Nature, 359, N6394, 380-387, 1992
FUN "Forrest GL &: BBA, 1048, N2-3, 149-155, 1990
LOC "Lemieux N &: Genomics, 15, N1, 169-172, 1993
LOC,MAP "McInnis MG &: Genomics, 16, N3, 562-571, 1993

SWI

SWISSPROT: P16152

KEY

lip

CLA

coding, basic

LOC

21 q22.12

MIM

MIM: 114830

EZN

ENZYME: 1.1.1.184

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