Gene: [22q112/ADORA2A] adenosine A2a receptor; [ADORA2 RDC8 ]

COM

Previously ADORA2/ADORA2A has been mapped to Chr 11q11-13 (by in situ hybridisation; Libert-1991; Szepetowski-1993). Later Libert et al. had verified the sequences of the clones used as probes in their localization study and concluded that their probe was not ADORA2. MacCollin-1994 located ADORA2 to Chr 22 based upon both analysis of cosmid clones from Chr 22 library and by Southern hybridization with a comprehensive somatic cell hybrid panel. By FISH Le-1996 localized the ADORA2A gene on Chr 22q11.2"

FUN

The adenosine receptors regulate cardiac rate, contractility, release of neurotransmitters, renal and other functions."

REF

MOP,EXP "Furlong TJ &: Mol Brain Res, 15, N1-2, 62-66, 1992
LOC "Le F &: BBRC, 223, N2, 461-467, 1996
HIS,COM,FAG "Libert F &: Genomics, 11, 225-227, 1991
PRO,COD "Libert F &: Science, 244, 569-572, 1989
PRO,LOC,EVO "MacCollin M &: Genomics, 20, 332-333, 1994
LIN,COM,HIS "Szepetowski P &: Genomics, 16, 745-750, 1993

KEY

nucm, recp, mem, neu

CLA

coding, basic

LOC

22 q11.2

MIM

MIM: 102776

SYN

ADORA2 RDC8

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