Gene: [02q35/XRCC5] X-ray repair complementing defective repair in Chinese hamster cells 5; thyroid autoantigen, 80kD (antigen Ku; p80; lupus antigen); ATP-dependent DNA helicase II, 86kD;

FAG

[1] An ATP-dependent DNA unwinding enzyme helicase II is a heterodimer of 70kD (GEM:22q13/TAKU) and 86kD subunits (Tuteja-1994).
[2] Ku autoantigen consists of 2 proteins of molecular mass of 70kD (GEM:22q13/TAKU) and 80kD. The p70/p80 complex binds to the folk-like ends of double-stranded DNA in a cell cycle-dependent manner."

REF

CLO,LOC "Blunt T &: Genomics, 30, 320-328, 1995
CLO,SEQ,FUN "Cai QQ &: CCG, 65, 221-227, 1994
LOC "Chen DJ &: Genomics, 21, 423-427, 1994
LOC "Chen DJ &: Genomics, 13, 1088-1092, 1992
CLO,SEQ,FUN "Genersch E &: EMBO J, 14, N4, 791-800, 1995
LOC "Jeggo PA &: PNAS, 89, 6423-6427, 1992
CLO,SEQ,FUN "Roberts MR &: PNAS, 91, 6354-6358, 1994
CLO,SEQ,FUN "Taccioli GE &: Science, 265, 1442-1445, 1994
CLO,SEQ,FUN "Tuteja N &: EMBO J, 13, 4991-5001, 1994

SWI

SWISSPROT: P13010

KEY

repr

CLA

coding, basic

LOC

02 q35

MIM

MIM: 194364

EZN

?

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